(no subject)

[quesarah]

Figure 3. When we examine a transfected system, basal activity is a measurable amount since there is a 1000 fold higher number of receptors compared to the native system. This means that there are 1000 times as many receptors that randomly assume the active conformation vs. native cells. Thus, constitutive receptor activity is measurable in the absence of agonist. In this case, addition of agonist alone also produces a classical concentration-response. Addition of antagonist alone will produce no response. Addition of the inverse agonist stabilizes the inactive conformation of the receptor and drives the equilibrium away from the active conformation. Thus addition of inverse agonist reduces the constitutive activity of the receptor and inhibits basal activity.


KEEN


1. http://medicine.creighton.edu/pharmacology/inverse.htm

Comments

[madenglishbloke.livejournal.com]

**whoosh**
thats just gone STRAIGHT over my head.
sounds impressive, though, so ill just nod and pretend i know what youre talking about

[biogeekgrrl.livejournal.com]

Good man. ;)

[mycorethoughts.livejournal.com]

Buh...?

[biogeekgrrl.livejournal.com]

Brushing up on my pharmacology for an interview. Thought I'd share. :)

[geli-tripping.livejournal.com]

Aieeeep??? (Monkey rattles his head in confusion)

[biogeekgrrl.livejournal.com]

It's about DRUGS, Sid. :)

[an-gealach.livejournal.com]

Ow. My brain hurts. ;)

[biogeekgrrl.livejournal.com]

It's just like, say you have a gate that is supposed to be closed most of the time, but really it can swing back and forth a little on its hinges. So you put a block or something to hold it shut.

That's basically what inverse agonists do, except they do that to receptor molecules on the surface of cells.

[an-gealach.livejournal.com]

Thanks for translating- now my brain doesn't hurt!

[biogeekgrrl.livejournal.com]

Yay! I win at teh science!